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Study of the Theranostic Pair RYZ811 (Diagnostic) and RYZ801 (Therapeutic) to Identify and Treat Subjects With GPC3+ (Glypican-3) Unresectable HCC

Exploring new ways to diagnose and treat liver cancer.

Recruiting
18 years and older
All
Phase 1/2
**Study Overview**: This study is testing a special treatment for liver cancer called hepatocellular carcinoma (HCC) that can't be removed with surgery. It uses two new medicines: RYZ811 to help doctors see the cancer (diagnostic) and RYZ801 to treat it (therapeutic). To join, you need to be at least 18 years old and have a confirmed diagnosis of HCC. **Eligibility**: You must have tried at least one other treatment before, have a certain liver cancer stage (BCLC Stage C or BCLC Stage B), and be in good health otherwise. You can't join if you have other specific types of liver cancer, other major health issues, or have had certain treatments before. **Key Points**: - **Duration**: The study is in two parts, Phase 1 and Phase 2, to test safety and effectiveness. - **Visits**: Regular check-ups and monitoring are required. - **Risks**: Possible side effects from the medicines, and eligibility is strict, so discuss with your doctor. Women must not be pregnant and everyone must use effective birth control methods. Always consult your doctor to see if this study is right for you.
Study details
    Hepatocellular Carcinoma (HCC)

NCT06726161

RayzeBio, Inc.

24 June 2026

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