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A Study to Compare the Efficacy and Safety of BMS-986393 Versus Standard Regimens in Adult Participants With Relapsed or Refractory and Lenalidomide-exposed Multiple Myeloma (QUINTESSENTIAL-2)

Comparing new treatment to standard for relapsed multiple myeloma.

Recruiting
18 years and older
All
Phase 3

This study is for adults with a type of blood cancer called Multiple Myeloma (MM), which has come back or not responded to treatment. It compares a new treatment, called arlo-cel (BMS-986393), with usual treatments. To join, you need to have had Relapsed or Refractory Multiple Myeloma (RRMM) and tried at least one but no more than three treatments before, including a drug named lenalidomide. The study checks if your organs work well and you feel strong enough to join (performance status 0 or 1).

Some people cannot join, like those with MM in the brain or who need urgent treatment. The main aim is to see if arlo-cel is better and safe compared to standard treatments for people who have been exposed to lenalidomide.

  • Duration: The study details on how long it lasts aren't specified, but participants will be monitored closely.
  • Visits: There will be multiple visits for treatment and check-ups.
  • Risks: As with any treatment, there might be side effects, which will be monitored.
Study details
    Relapsed or Refractory Multiple Myeloma (RRMM)

NCT06615479

Juno Therapeutics, Inc., a Bristol-Myers Squibb Company

24 June 2026

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Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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