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Study of Iopofosine I 131 (CLR 131) in Select B-Cell Malignancies (CLOVER-1) and Pivotal Expansion in Waldenstrom Macroglobulinemia

Clinical trial for B-cell cancers and Waldenstrom Macroglobulinemia.

Recruiting
18 years and older
All
Phase 2
  • Simplified description (AI rewritten)
  • Technical description (Original)

This study is about a special medicine called iopofosine I 131, used to treat certain B-cell malignancies (cancers of the blood cells). These include diseases like multiple myeloma, a bone marrow cancer, and Waldenstrom Macroglobulinemia (WM), a type of non-Hodgkin lymphoma. This study has two parts. Part A checks how well iopofosine I 131 works in various B-cell cancers that have been hard to treat with regular medicines. Part B focuses on patients with WM who have already tried at least two different treatments. Iopofosine I 131 is a type of radiotherapy, meaning it uses radiation to target and kill cancer cells. It is specifically designed to enter these cancer cells and destroy them from the inside. This medicine has shown promise in experimental models, which means it could potentially help people with these challenging diseases.

  • Participation involves receiving the medicine through an IV (intravenous) line.
  • Eligible patients must have tried other treatments before and still need help.
  • Some risks may include side effects from radiation or other medical concerns.
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Study details
    Multiple Myeloma

NCT02952508

Cellectar Biosciences, Inc.

11 July 2024

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What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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