This study explores if a medicine called spironolactone, commonly used for high blood pressure, is safe for older African American adults with memory problems, known as mild cognitive impairment (MCI), and early Alzheimer's disease. The study will last one year, where participants will take either spironolactone or a placebo (a pill with no medicine) and visit the study center 4 to 5 times. Researchers will check how the medicine affects memory and thinking skills using special tests.

Key Points:

• Participation lasts for one year with 4-5 study visits.
• Participants will take either spironolactone or a placebo.
• Researchers will test memory and thinking skills and check for side effects.

Spironolactone works by blocking a hormone called aldosterone, which affects blood pressure and brain health. The study aims to find out if this drug can help maintain memory and thinking skills in older African Americans. Eligible participants must be African American, have controlled blood pressure, and show signs of MCI. This study could lead to new treatments for memory problems in the future.