**Frontotemporal Lobar Degeneration (FTLD)** is a brain disorder affecting behavior, language, and movement. The ALLFTD study examines both sporadic (not family-related) and familial (family-related) types of FTLD. It involves two parts: a "longitudinal arm" with yearly check-ups, and a "biofluid-focused arm" for collecting biological samples.
Participants in the "longitudinal arm" are family members of those with known FTLD genes, or have a family history of FTLD. Sporadic participants should show symptoms without a family history. They may have conditions like Progressive Supranuclear Palsy (PSP) or Behavioral variant Frontotemporal Dementia (bvFTD). The "biofluid-focused arm" includes any FTLD participants, and fewer clinical tests are needed.
- **Commitment**: Annual visits for comprehensive data collection in the longitudinal arm.
- **Eligibility**: Family history or specific symptoms are needed for participation.
- **Exclusions**: Conditions like Alzheimer's, severe alcohol use, or certain brain lesions may disqualify participants.
For more details, visit the study's website: https://www.allftd.org/