This study looks at how ketamine affects people with Major Depressive Disorder (MDD), focusing on how they make decisions and feel emotions. Ketamine is often used to relieve pain during surgery, but here it's given in smaller amounts to see if it helps with depression symptoms like anhedonia, which is finding no joy in things you used to like.
Participants will either have MDD or be healthy volunteers. Those with MDD will receive ketamine or a placebo (a fake treatment) to see how their brain responds to stress. Healthy volunteers will not receive any treatment but will help provide a baseline for tests. These tests include answering questions, brain scans, and performing tasks.
- Length: Participants will need to attend multiple sessions for tests and scans.
- Treatment: MDD participants may receive ketamine or placebo.
- Eligibility: MDD participants must be off antidepressants for at least 8 weeks.
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