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Intra-ovarian Injection of MSC-EVs in Idiopathic Premature Ovarian Failure

Testing MSC-EVs injections for early ovarian failure.

Recruiting
20-38 years
Female
Phase 1/2
  • Simplified description (AI rewritten)
  • Technical description (Original)

Premature Ovarian Failure (POF) is when a woman's ovaries stop working before age 40. This can lead to irregular periods or no periods (called amenorrhea) and low levels of the hormone estradiol. A new study is exploring the use of extracellular vesicles (EVs) from mesenchymal stromal cells (MSCs), which are tiny packages released by cells, to treat POF. These MSC-EVs might help by delivering signals to the ovaries without causing harmful side effects like tumors or immune reactions.

The study involves injecting these MSC-EVs directly into the ovaries of 10 women diagnosed with POF. Participants will be monitored for 8 months to see if their hormone levels improve and if their menstrual cycles return. The injection might cause some short-term side effects like fever or infection, and these will be checked closely.

  • Study lasts 8 months with regular check-ups.
  • Participants will receive a single injection of MSC-EVs.
  • Possible risks include fever and infection, monitored closely.
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Study details
    Premature Ovarian Failure

NCT06202547

Royan Institute

24 January 2024

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